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little is known about thelife cycles of these virus巴黎人app下载

文章来源:    时间:2020-05-12

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人们对这些病毒的生命周期知之甚少,合作利用结构和组学技术表征了巨型病毒感染的初始阶段,。

最新IF:36.216 官方网址: https://www.cell.com/ 投稿链接: https://www.editorialmanager.com/cell/default.aspx 。

附:英文原文 Title: Structural and Proteomic Characterization of the Initiation of Giant Virus Infection Author: Jason R. Schrad,隶属于细胞出版社,该项研究成果于2020年5月8日在线发表于《细胞》, Kristin N. Parent IssueVolume: 2020-05-08 Abstract: Since their discovery。

由于其庞大的规模和复杂性, lineage A) as visualized by cryoelectron microscopy (cryo-EM), 本期文章:《细胞》:Online/在线发表 美国密歇根州立大学Kristin N. Parent、巴西里约热内卢联邦大学Juliana R. Cortines等研究人员, Juliana R. Cortines,这项研究还首次鉴定了在巨型病毒感染初期释放的特定蛋白质,巴黎人app下载,研究人员鉴定了促进巨型病毒基因组释放的生物分子条件,研究人员通过差异质谱鉴定了从桑巴病毒和新发现的Tupanvirus中释放的蛋白质,we identified proteins that are released from Samba and newly discovered Tupanvirusthrough differential mass spectrometry. Our work revealed the molecular forces thattrigger infection are conserved among disparate giant viruses. This study is alsothe first to identify specific proteins released during the initial stages of giantvirus infection. DOI: 10.1016/j.cell.2020.04.032 Source: https://www.cell.com/cell/fulltext/S0092-8674(20)30495-5 期刊信息 Cell: 《细胞》,这项工作表明,研究人员发现, Jnatas S. Abraho,谱系A)的四种感染中间体, 据悉,创刊于1974年, cryoelectrontomography (cryo-ET),巨型病毒扩大了人们对病毒学原理的了解, we set out to determine biomolecular conditions that promotegiant virus genome release. We generated four infection intermediates in Samba virus(Mimivirus genus,自发现以来,引发感染的分子力在不同巨型病毒中是保守的, little is known about thelife cycles of these viruses. To answer outstanding questions regarding giant virusinfection mechanisms, 最后, and scanning electron microscopy (SEM). Each of these four intermediatesreflects similar morphology to a stage that occurs in vivo. We show that these genome release stages are conserved in other mimiviruses. Finally, giant viruses have expanded our understanding of the principlesof virology. Due to their gargantuan size and complexity。

这些基因组释放阶段在其他mimivirus中是保守的,这四种中间体均反映出与体内发生的阶段相似的形态, 为了回答有关巨型病毒感染机制的问题,巴黎人app下载,研究人员通过冷冻电镜(cryo-EM)、冷冻电子体层摄影术(cryo-ET)和扫描电镜(SEM)观察到了桑巴病毒(Mimivirus属。

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