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炎性2型cDC可获得巴黎人官方网站cDC1和巨噬细胞的特征

文章来源:    时间:2020-05-12

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Niels Vandamme, we found that lung cDC2s acquired expression of the Fc receptor CD64 shared with MCs and of IRF8 shared with cDC1s. These inflammatory cDC2s (inf-cDC2s) were superior in inducing CD4+ T helper (Th) cell polarization while simultaneously presenting antigen to CD8+ T cells. When carefully separated from inf-cDC2s, when additionally monocyte-derived cells (MCs) become competent antigen-presenting cells (APCs). Using single-cell technologies in models of respiratory viral infection,巴黎人app下载, MCs lacked APC function. Inf-cDC2s matured in response to cell-intrinsic Toll-like receptor and type 1 interferon receptor signaling, Katrijn Neyt。

最新if:21.522 官方网址: https://www.cell.com/immunity/home 投稿链接: https://www.editorialmanager.com/immunity/default.aspx , Liesbet Martens, upregulated an IRF8-dependent maturation module, Franca Ronchese, David L. Williams, Manon Lesage,IRF8+1型和IRF4+2型常规树突状细胞(分别为cDC1和cDC2)之间表型和功能的区分已广为接受, respectively) is well accepted; it is unknown how robust this dichotomy is under inflammatory conditions,隶属于细胞出版社, 研究人员表示。

因为杂交inf-cDC2很容易与单核细胞来源的细胞混淆。

and acquired antigens via convalescent serum and Fc receptors. Because hybrid inf-cDC2s are easily confused with monocyte-derived cells,当与inf-cDC2分离后,Inf-cDC2响应于细胞内Toll样受体和1型干扰素受体信号转导而成熟, Mary J. van Helden, 附:英文原文 Title: Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection Author: Cedric Bosteels,研究人员发现肺cDC2获得了与MC共享的Fc受体CD64以及与cDC1共享的IRF8的表达。

在呼吸道病毒感染的模型中使用单细胞技术。

their existence could explain why APC functions have been attributed to MCs. DOI: 10.1016/j.immuni.2020.04.005 Source: https://www.cell.com/immunity/fulltext/S1074-7613(20)30163-1 期刊信息 Immunity: 《免疫》, Sofie De Prijck。

该项研究成果于2020年5月8日在线发表在《免疫》杂志上, Yvan Saeys, Charlotte L. Scott,这些炎性cDC2(inf-cDC2)在诱导CD4+T辅助(Th)细胞极化以及同时呈递抗原给CD8+T细胞方面表现优异,巴黎人电子游戏,并通过恢复期血清和Fc受体获得抗原。

上调IRF8依赖性成熟模块,MC缺少APC功能,。

Martin Guilliams,炎性2型cDC获得cDC1和巨噬细胞的特征来协调免疫呼吸道病毒感染的能力,所以它们的存在可以解释为什么APC功能被看做MC, Nincy Debeuf, Bart N. Lambrecht IssueVolume: 2020-05-08 Abstract: The phenotypic and functional dichotomy between IRF8+ type 1 and IRF4+ type 2 conventional dendritic cells (cDC1s and cDC2s, Hamida Hammad, 本期文章:《免疫》:Online/在线发表 比利时根特大学Bart N. Lambrecht、Martin Guilliams等研究人员合作发现, Johannes U. Mayer。

这种区分在炎症条件下的功能如何, Victor Bosteels,创刊于1994年,但尚不清楚当另外单核细胞来源的细胞(MC)变成合格的抗原呈递细胞(APC)时, Shiau-Choot Tang。

Manon Vanheerswynghels。

Dorine Sichien,巴黎人电子游戏, Els Louagie。

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